Endocrine Abstracts

Glucocorticoid receptor (GR) is a hormone-dependent nuclear transcription factor that modulates the expression of genes involved in development, inflammation, and metabolism. In addition, as GR is a key factor in several steroid dependent cancers steroid hormones are extensively used in the treatment of cancers such as leukemia. The transcriptional activity of GR is cell type specific and its magnitude and target selectivity depend on multiple factors including posttranslation...